MUC4 (mucin 4, cell surface associated)
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چکیده
منابع مشابه
MUC 4 ( mucin 4 , cell surface associated )
Hugo: MUC4 Other names: sv0-MUC4 Location: 3q29 Note: MUC4 belongs to the human mucin family, and more specifically to the subgroup of the membraneanchored mucin. It is an O-glycoprotein that can extend up to 2 micrometer over the cell membrane. It is suggested that MUC4 is translated as a single precursor polypeptide, which is further cleaved at a GDPH site in two subunits, MUC4a and MUC4b. MU...
متن کاملComplete sequence of the human mucin MUC4: a putative cell membrane-associated mucin.
The MUC4 gene, which encodes a human epithelial mucin, is expressed in various epithelial tissues, just as well in adult as in poorly differentiated cells in the embryo and fetus. Its N-terminus and central sequences have previously been reported as comprising a 27-residue peptide signal, followed by a large domain varying in length from 3285 to 7285 amino acid residues. The present study estab...
متن کاملMUC 16 ( mucin 16 , cell surface associated )
As per the present available information, there is a discrepancy regarding the total number of exons present in MUC16 genomic DNA. This discrepancy is due to the absence/presence of some of the genomic sequences (particularly for the repeat regions) in the available genomic databases. The terminal nine exons on both 5' and 3' ends code for the aminoand carboxyterminal domains of MUC16, respecti...
متن کاملQuantification of MUCIN 1, cell surface associated and MUCIN16, cell surface associated proteins in tears and conjunctival epithelial cells collected from postmenopausal women
PURPOSE To quantify the expression of mucin 1, cell surface associated (MUC1) and mucin 16, cell surface associated (MUC16) proteins and messenger ribonucleic acid (mRNA) in a cohort of postmenopausal women (PMW), to explore the relationship between mucin expression, dry eye symptomology, and tear stability. METHODS Thirty-nine healthy PMW (>50 years of age) were enrolled in this study. No sp...
متن کاملMUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins.
MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas. Recent studies have shown that the expression of MUC4 is associated with the progression of pancreatic cancer and is inversely correlated with the prognosis of pancreatic cancer patients. In the present study, we have examined the phenotypic and molecular conse...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38441